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© 1972 British Society for Rheumatology

other

MULTIPLE MYELOMA WITH SYNOVIAL AMYLOID DEPOSITION

H. RALPH SCHUMACHER, Jr.*

Arthritis Section, Department of Medicine, University of Pennsylvania School of Medicine and Veterans Administration Hospital Philadelphia, Pennsylvania, US.A.

A 56-year-old man developed multiple myeloma with severe joint stiffness and arthralgia without definite joint swelling. At post-mortem examination large amounts of amyloid were found by light and electron microscopy in the synovial fluid and on the surface of the synovial membrane. Smaller amounts of amyloid were identified beneath the lining cells and in vessel walls. No inflammatory reaction was found in the synovial membrane or fluid. Synovial amyloid may occasionally be responsible for joint stiffness and arthralgia, as well as for more marked joint changes mimicking rheumatoid arthritis. The diagnosis can be established by synovial biopsy.

*Supported in part by funds from the Veterans Administration, and grants from the Arthritis Foundation, Eastern Pennsylvania Chapter, and Smith, Kline and French Laboratories.


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