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© 1973 British Society for Rheumatology

research-article

ACCUMULATION OF 125I-LABELLED ALBUMIN AS A MEASURE OF THE INFLAMMATORY RESPONSE IN EXPERIMENTAL ARTHRITIS*

C. SORIA-HERRERA{dagger}

Kennedy Institute of Rheumatology, Hammersmith, London, W.6

This paper describes an in-vivo method developed for testing the response of animals with experimental arthritis to anti-inflammatory drugs. The method is suitable for the study of experimental arthritis caused by conventional inflammatory agents such as turpentine, or for the investigation of hypersensitivity arthritis in small animals. The techniques described in this paper have been shown to be sensitive indicators of changed vascular permeability in animals with arthritis; they provide ready means of measuring these responses. In addition, they give a positive and precise means of assessing the anti-inflammatory activity of pharmacological compounds.

*Based on a paper read at a combined meeting of the British Association of Physical Medicine and Rheumatology and the Royal Society of Medicine (Physical Medicine Section), Coventry, October 1972.

{dagger}Present address: Department of Rheumatology, Arthur Stanley House, Middlesex Hospital, London, W.


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