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© 1973 British Society for Rheumatology

research-article

IMMUNOLOGICAL ASPECTS OF CHRYSOTHERAPY*

R. A. BILLINGS{dagger}, R. GRAHAME{dagger}, SUZANNE ALEXANDER{ddagger}, P. PARKES{ddagger}, V. MARKS§ and A. TAYLOR§

{dagger}Guy's Arthritis Research Unit
{ddagger}Department of Medicine, Guy's Hospital London, SE1
§Department of Biochemistry, Surrey University Guildford

In this study of cell-mediated immunity in relation to skin rashes occurring during gold therapy, evidence is provided that immune sensitization to gold, as judged by the lymphocyte transformation test and macrophage migration inhibition test (MIF), may occur in a proportion of patients. Out of the 40 patients receiving gold, 14 developed rashes and 7 (50%) of these had abnormal immunological reactions.

*Based on a paper read at the Annual Meeting of the British Association for Rheumatology and Rehabilitation, London, March 1973.


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