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© 1974 British Society for Rheumatology

research-article

A SEQUENTIAL TRIAL OF INDOMETHACIN AND SODIUM AMYLOBARBITONE AT NIGHT IN RHEUMATOID ARTHRITIS, WITH COMMENTS ON THE STATISTICAL METHOD*

M. F. GRAYSON{dagger} and E. C. HUSKISSON{ddagger}

{dagger}Royal Free Hospital London.
{ddagger}St. Bartholomew's Hospital London

Disturbed sleep in cases of rheumatoid arthritis is better treated with an anti-inflammatory analgesic than a hypnotic.

INDOMETHACIN 100 mg at night as a suppository (Holt and Hawkins, 1965) or capsules (Huskisson et al., 1970) relieves night pain in rheumatoid arthritis. Hypnotics are also widely prescribed for chronic musculoskeletal disorders (Johnson and Clift, 1968).

Indomethacin at night was therefore compared with sodium amylobarbitone in rheumatoid arthritis. Subsequently, indomethacin plus sodium amylobarbitone was compared with indomethacin alone.

*Paper read at the Annual Meeting of the British Association for Rheumatology and Rehabilitation, London, April 1974.


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