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© 1975 British Society for Rheumatology

research-article

ANKYLOSING RHEUMATOID ARTHRITIS*

R. GRAHAME, A. CALIN, M. TUDOR, L. KENNEDY and A. PERRIN

Guy's Arthritis Research Unit London SE1 9RT

The study concerns the clinical, haematological, serological, radiological and histocompatibility antigenic status of eleven in-patients suffering from long-standing sero-positive rheumatoid arthritis at the Royal Hospital and Home for Incurables in London. The study revealed a striking degree of widespread bony ankylosis affecting the peripheral joints and cervical spine. In large part, this bony ankylosis accounted for the disability but it is considered that the cervical spine ankylosis may protect the spinal cord from damage. The absence of the histo-compatability antigen HLA 27 is a useful pointer in the exclusion of Ankylosing Spondylitis. Despite the clinical impression that the disease was inactive, the elevated sedimentation rate (23-66, mean 41 mm) suggests that the rheumatoid process remains active.

*Paper presented at a combined meeting of the British Association for Rheumatology and Rehabilitation, the Heberden Society, the Rheumatology and Rehabilitation Section of the Royal Society of Medicine, and the Swiss Society for Rheumatology, Bristol, June 1974.


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