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© 1975 British Society for Rheumatology

other

PHENYLBUTAZONE AND HEPATITIS

P. D. FOWLER*, DOUGLAS WOOLF{dagger} and SUZANNE ALEXANDER{ddagger}

*Medical Department, Geigy Pharmaceuticals Macclesfield
{dagger}Chingford Hospital London E4
{ddagger}Department of Medicine, Guy's Hospital London SE1 9RT

During a comparative trial between enteric-coated and rectally administered phenylbutazone in patients with rheumatoid disease, one patient developed a mild hepatitis. She had recently concluded a long period of gold therapy. The natural history of phenylbutazone hepatitis is reviewed on the basis of 41 case histories, and the experience with this individual patient interpreted accordingly.


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