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© 1975 British Society for Rheumatology

research-article

CUTANEOUS EXTENSIBILITY IN HEALTH AND DISEASE*

R. GRAHAME and W. HARVEY

Guy's Arthritis Research Unit, Guy's Hospital London SE1 9RT

The results are recorded of a number of studies performed over the last few years using a simple and reproducible method for investigating the extensibility of intact skin. A major advantage of this method lies in the fact that it causes the patient no discomfort and leaves his skin without blemish. We have found abnormal behaviour of skin in response to applied stress in the heritable connective tissue disorders: Ehlers-Danlos Syndrome, cutis laxa, and pseudoxanthoma elasti-cum, and in the acquired disorders of acromegaly, hypopituitarism and scleroderma. An abnormal elastic modulus, however, was found only in pseudoxanthoma elasticum and the growth-hormone disorders.

*Paper presented to Symposium on Collagen in Health and Disease, Bristol, September, 1974.


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