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© 1976 British Society for Rheumatology

review-article

AUTO-IMMUNE DISEASE

G. S. PANAYI*

Department of Medicine and Guy's Arthritls Research Unit, Guy's Hospital Medical School London SEI 9RT

Auto-immune disease may result from the interaction of the genetic load of the individual, modification of self-tissue antigens by environmental agents such as virus or drugs and abnormalities of the immunological system itself such as the loss of controlling or suppressor T cells with age. In the majority of people the outcome is tolerance, maintenance of normal tissue architecture and function. In the unfortunate few the outcome is auto-immune disease, that is, failure to recognize ‘self’.

*Senior Lecturer in Rheumatology


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