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© 1976 British Society for Rheumatology


other

THE EFFECT OF LOW DOSES OF PREDNISOLONE COMPARED WITH PLACEBO ON FUNCTION AND ON THE HYPOTHALAMIC PITUITARY ADRENAL AXIS IN PATIENTS WITH RHEUMATOID ARTHRITIS

M. ANNE CHAMBERLAIN* and J. KEENAN{dagger}

Arthur Stanley House, The Middlesex Hospital, and the Courtauld Institute London, W1

A double-blind trial of prednisolone in patients with rheumatoid arthritis using doses of zero, 3 mg and 5 mg is reported. Patients on a dose of 3 mg derived little sustained benefit but subjects on the higher dose showed some improvement which did not last more than two years. Mild suppression of the hypothalamo-pituitary-adrenal axis occurred in both steroid-treated groups.

*Present address: Department of Rheumatology and Rehabilitation, The General Infirmary, Leeds.

{dagger}Present address: Department of Chemical Pathology, King's College Hospital, London


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