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© 1976 British Society for Rheumatology

other

HL-A 27-ASSOCIATED ARTHRITIS

A. C. KEAT and R. M. R. BARNES

St. Stephen's Hospital Fulham Road, London, SW10
Department of Haematology, Charing Cross Hospital Medical School Fulham Palace Road, London, W6 8RF

Correspondence to: Requests for reprints to Dr. A. C. Keat, Tissue Typing Laboratory, Department of Haematology, Charing Cross Hospital, Fulham Palace Road, London W6 8RF.

Seventy-one of 78 patients presenting to routine rheumatology clinics with seronegative arthritis were found to possess the histocompatibility antigen HL-A 27. Four principal components to their arthritis emerged, namely: spondylitis, sacroiliitis, peripheral polyarthritis, oligoarthritis (involvement of one or two large joints). It is suggested that each of these may be influenced by separate genetic determinants. The various combinations in which these occur warrant a unified nomenclature.

A small subgroup of patients with HL-A 27-associated arthritis is described in whom the diseases may be especially benign.


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