Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by McCONKEY, B.
Right arrow Articles by CONSTABLE, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCONKEY, B.
Right arrow Articles by CONSTABLE, T. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1976 British Society for Rheumatology

research-article

DAPSONE IN RHEUMATOID ARTHRITIS

B. McCONKEY1,, P. DAVIES2, R. A. CROCKSON1, A. P. CROCKSON1, M. BUTLER2 and T. J. CONSTABLE1

1Dudley Road Hospital and the Department of Experimental Pathology, Birmingham University
2Department of Mathematical Statistics, Birmingham University

Correspondence to: Reprints from: Dr B. McConkey, Dudley Road Hospital, PO Box 293, Birmingham B18 7QH.

After a preliminary period of observation, 71 patients with consistently active rheumatoid arthritis (RA) were given dapsone 50 mg daily for one week, then 100 mg daily. There was a significant improvement in subjective clinical state and there were significant falls in serum C-reactive protein (CRP) and the ESR; the Rose-Waaler titre (RW) did not fall.

The results were compared with those in 78 patients who had gold. Subjective clinical improvement was slower with gold, but from six weeks the pattern of changes in clinical score, CRP and ESR was similar for both drugs. The RW fell during gold treatment.

The results suggest dapsone is effective in RA; over-all it appears to be slightly less effective than gold but much less toxic.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.