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© 1976 British Society for Rheumatology

other

COLITIS AND DEATH FOLLOWING GOLD THERAPY

Y. SIEGMAN-IGRA, M. YARON, M. SILETZKI, E. SCHUJMAN and T. GILAT

Departments of Internal Medicine, Physical Medicine and Rheumatology, Pathology and Gastro-enterology, Tel-Aviv Government Municipal Hospitals and Tel-Aviv University Sackler School of Medicine

A 45-year-old female with classical rheumatoid arthritis was started on Myocrisin injections. After receiving 130 mg Myocrisin (equivalent to 65 mg gold) she developed severe diarrhoea which was unresponsive to steroids, British Anti-Lewisite (B.A.L.) and all other conservative treatments. A rectal biopsy showed severe inflammation. Malabsorption of fat and carbohydrate was demonstrated. During hospitalization diarrhoea continued, she developed hypoproteinaemia and died. Post-mortem examination revealed severe lung infection with abscess formation and severe changes in the colon. Gold concentrations in different organs are reported.


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