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© 1977 British Society for Rheumatology

other

LACTOFERRIN IN SYNOVIAL FLUID

U. AMBANELLI, W. TROISE, G. F. FERRACCIOLI and G. SERVENTI

Department of Rheumatology, University of Parma Italy

The synovial lactoferrin (LF) concentrations of 59 patients with active rheumatoid arthritis were determined. The median value of LF was 4.64±3.59 mg/100 ml, but in degenerative arthropathy the levels of the metal-protein were much lower and often not titratable.

These variations in the LF concentration explain the low blood-iron levels in inflammatory states, even when the concentration of the metal-protein is not statistically correlated in inflammatory tests, IgG, complement fractions (of the normal or alternate pathway), or variations of other protein fractions of leucocyte origin.


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