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© 1977 British Society for Rheumatology

meeting-report

ANKYLOSING SPONDYLITIS: KLEBSIELLA AND HL-A B27*

ROLAND EBRINGER1, DOMINICK COOKE1, D. R. CAWDELL1, P. COWLING2 and ALAN EBRINGER2

1Departments of Rheumatology and Bacteriology, Middlesex Hospital London W1P 9PG
2Immunology Unit, Departments of Biochemistry and Bacteriology, Queen Elizabeth College London W8 7 AH

A search for the presence of Klebsiella-Enterobacter spp. and Yersinia enterocolitica in urine and faeces of 63 patients with ankylosing spondylitis was conducted because these microorganisms have been demonstrated to cross-react immunologically with HL-A B27 positive lymphocytes. The patients were graded into three groups on the basis of disease activity. Klebsiella spp. were found in the faeces of 13 (93%) of the 14 patients with ‘active’ disease, 10 (48%) of the 21 patients with ‘probably active’ disease and in one (4%) of the 28 patients with ‘inactive’ disease. Positive cultures were also obtained in 47 (38%) of 124 controls. It is suggested that the presence of Klebsiella spp. in faecal cultures may be associated with ‘active’ disease in patients with ankylosing spondylitis.

* Paper read at a combined meeting of the Heberden Society, the British Association for Rheumatology and Rehabilitation, the Royal Society of Medicine Section of Rheumatology and Rehabilitation and the Irish Society for Rheumatology and Rehabilitation, Dublin, October 15, 1976.


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