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© 1978 British Society for Rheumatology

research-article

THE BIOAVAILABILITY OF BENORYLATE IN HOT BEVERAGES

NICOLA A. BARRETT, M. E. PICKUP, J. R. LOWE, V. WRIGHT and W. W. DOWNIE

Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, and the Rheumatism Research Unit, University Department of Medicine, General Infirmary at Leeds

Correspondence to: Requests for reprints to Dr. M. E. Pickup, Clinical Pharmacology Unit (Rheumatism Research), Royal Bath Hospital, Cornwall Road, Harrogate HGI 2PS

It has been recommended that benorylate may be administered with hot beverages to overcome the problem of its relative unpalatability. Urine salicylate recovery used as a measure of bioavailability in 20 normal subjects has shown that hot coffee has no significant effect on drug availability from the orally administered suspension.


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