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© 1979 British Society for Rheumatology

research-article

DIFLUNISAL AND ASPIRIN: A COMPARTISON OF EFFICACY AND NEPHROTOXICITY IN OSTEOARTHRITIS

P. A. DIEPPE and E. C. HUKISSON

Department of Rheumatology, St. Bartholomew's Hospital London ECIA 7BE

Correspondence to: Request for reprints to Dr. P. A. Dieppe

Diflunisal was more effective than aspirin in the treatment of osteoarthritis in a double-blind trial. It was better tolerated than aspirin and caused fewer withdrawals from treatment. Diflunisal also had the advantage of a twice daily dosage schedule. Diflunisal caused less increase in cell and lysosomal enzyme excretion by the kidney.


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