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© 1979 British Society for Rheumatology

research-article

A DOUBLE-BLIND CROSS-OVER EVALUATION OF KETOPROFEN (ORUDIS) AND IBUPROFEN IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS

F. MONTRONE1,, M. FUMAGALLP1, P. PELLEGRINI2, G. RATTI3, G. SALA4, C. LIVERTA5, C. POLLINI5 and A. E. PONTIROLP5

1Servizio di Reumatologia, Ospedale Luigi Sacco 20157 Milan
2Reparto di Reumatologia, Ospedale S. Anna Ferrara
3Divisione Medica 1, Ospedale Civile Busto Arsizio
4Divisione B di Medicina, Ospedale di Circolo Varese
5Direzione Medica Farmitalia Milan, Italy

Correspondence to: Requests for reprints to Dr. F. Montrone

In a multi-centre double-blind cross-over trial using the double-placebo technique, 55 patients with rheumatoid arthritis were treated for 10 days for each trial drug with ketoprofen (200 mg/day) and ibuprofen (1200 mg/day). Both drugs induced a clinically and statistically significant improvement of all the symptoms studied, except for pain at night during ibuprofen administration. Ketoprofen displayed a therapeutic efficacy significantly superior to ibuprofen in five out of the eight symptoms studied.

Side-effects were recorded in 10 patients receiving ketoprofen (one patient withdrew because of heartburn) and in nine patients receiving ibuprofen.


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