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© 1980 British Society for Rheumatology

research-article

NAPROXEN SODIUM AND INDOMETHACIN IN ACUTE MUSCULOSKELETAL DISORDERS

C. I. BACKHOUSE1, CORINA ENGLER2, and J. R. ENGLISH2

1The Surgery Kingston Avenue, East Horsley, Surrey KT24 6QT
2Syntex Pharmaceuticals Limited Maidenhead, Berkshire SL6 IRD

Correspondence to: Requests for reprints to Dr. Corina Engler.

One hundred and fourteen patients suffering from musculoskeletal disorders were entered into a double-blind, parallel comparison of naproxen sodium (825 mg daily) and indomethacin (75 mg daily). The two treatment groups were found to be matched for age, sex, history of disorder and severity of symptoms at the start of the study. At the seven-day follow-up both groups of patients showed statistically significant reductions from baseline in pain and limitation of movement. Patients' daily records showed a steady decline of symptom severity throughout the seven days. There were no significant differences between the effects of the two drugs. The numbers of patients with side-effects and the total number of complaints in the two treatment groups were not significantly different but there were significantly more patients complaining of headache (P = 0.018) and diarrhoea (P = 0.034) in the indomethacin group. Nine patients withdrew from the study—three patients taking naproxen sodium and six taking indomethacin—all because of side-effects.


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