Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by NAHIR, A. M.
Right arrow Articles by SCHARF, Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by NAHIR, A. M.
Right arrow Articles by SCHARF, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1980 British Society for Rheumatology

research-article

A COMPARATIVE STUDY OF DICLOFENAC AND SULINDAC IN ANKYLOSING SPONDYLITIS

A. M. NAHIR and Y. SCHARF

The B. Shine Department of Rheumatology Rambam Medical Center Faculty of Medicine-Technion Haifa, Israel

Correspondence to: Requests for reprints to Dr. A. M. Nahir.

A double-blind between-patient comparison of diclofenac sodium (Voltaren) 150 mg daily and sulindac 400 mg daily in 62 patients with active ankylosing spondylitis was carried out. After a seven-day wash-out period in which current anti-inflammatory drugs were tailed off, patients were entered into the trial and treated for four weeks. Both drugs significantly reduced the activity of the disease.

There were no statistically significant differences between the effects of the two drugs, although diclofenac appeared to be marginally more effective. In respect of finger-floor distance, the difference was statistically significant (P <0.01) in favour of diclofenac. Subjective assessment by the patient and the physicians both favoured diclofenac but the difference was not statistically significant. Adverse reactions were mild and occurred slightly more frequently in the sulindac group. No significant laboratory abnormalities were found.

The present work has shown that diclofenac has a useful role in the management of ankylosing spondylitis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.