© 1981 British Society for Rheumatology
research-article |
HEPATIC INJURY FOLLOWING FEPRAZONE THERAPY
1Selly Oak Hospital Birmingham
2Rheumatism Research Wing Rheumatism Research Wing
Correspondence to:
Requests for reprints to Dr. D. L. Scott, Department of Investigative Pathology, Rheumatism Research Wing, University of Birmingham, Birmingham B15 2TJ.
Two cases of feprazone-induced hepatic injury are reported. Both patients developed jaundice within one month of commencing therapy. Histological investigation showed a granulomatous reaction in one case and hepatitic changes in the other. The changes were similar to those seen as a complication of phenylbutazone therapy. When the administration of feprazone was discontinued both the clinical and biochemical changes were resolved.