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© 1981 British Society for Rheumatology


research-article

HEPATIC INJURY FOLLOWING FEPRAZONE THERAPY

J. WIGGINS1 and D. L. SCOTT2,

1Selly Oak Hospital Birmingham
2Rheumatism Research Wing Rheumatism Research Wing

Correspondence to: Requests for reprints to Dr. D. L. Scott, Department of Investigative Pathology, Rheumatism Research Wing, University of Birmingham, Birmingham B15 2TJ.

Two cases of feprazone-induced hepatic injury are reported. Both patients developed jaundice within one month of commencing therapy. Histological investigation showed a granulomatous reaction in one case and hepatitic changes in the other. The changes were similar to those seen as a complication of phenylbutazone therapy. When the administration of feprazone was discontinued both the clinical and biochemical changes were resolved.


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