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© 1981 British Society for Rheumatology


research-article

ISOXEPAC IN RHEUMATOID ARTHRITIS: A DOUBLE-BLIND COMPARISON WITH ASPIRIN

L. S. GERLIS and J. M. GUMPEL

Division of Rheumatology, Northwick Park Hospital and Clinical Research Centre Harrow, Middlesex HA1 3UJ

Correspondence to: Requests for reprints to Dr. J. M. Gumpel.

Nineteen patients with rheumatoid arthritis entered a double-blind cross-over study, comparing a new anti-inflammatory agent isoxepac, 200 mg three times daily, with aspirin 1.2 g three times daily. Eighteen patients completed 2–4 weeks treatment with each drug. The treatments were similar when assessed by measurement of joint pain, grip strength, morning stiffness, patients’ global assessment and overall preference. Significantly fewer adverse effects were associated with isoxepac therapy when compared with aspirin therapy.


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