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© 1981 British Society for Rheumatology

research-article

PROBLEMS IN THE ASSESSMENT OF DISEASE ACTIVITY IN ANKYLOSING SPONDYLITIS

D. G. I. SCOTT, E. F. J. RING and P. A. BACON

Royal National Hospital for Rheumatic Diseases Bath, Avon

Correspondence to: Requests for reprints to Dr. D. G. I. Scott

Serial assessments of disease activity using clinical, laboratory and thermographic indices were made on 20 patients with ankylosing spondylitis (AS) before and after active in-patient exercise classes and two months after discharge. Clinical measurements and the erythrocyte sedimentation rate suggested decreased activity by the time of the final assessment but plasma viscosity and thermography suggested increased activity and levels of C-reactive protein were unchanged. Functional improvement occurred mostly during the in-patient period. A wide range of complement levels was found but did not change, and IgG rheumatoid factor levels were negative through-out. The problems of laboratory assessment in AS are stressed.


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