Skip Navigation

Cardiovascular Research 1987 21(3):161-168; doi:10.1093/cvr/21.3.161
© 1987 by European Society of Cardiology
This Article
Right arrow Full Text (PDF)
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by WHITTLE, M A.
Right arrow Articles by ANDERSON, J. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WHITTLE, M A.
Right arrow Articles by ANDERSON, J. C
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1987, European Society of Cardiology

Biochemical investigation of possible lesions in human aorta that predispose to dissecting aneurysms: pyridinoline crosslinks

M ANNE WHITTLE*, SIMON P ROBINS{dagger}, PHILIP S HASLETON{ddagger} and JOHN C ANDERSON*

* From the Department of Biochemistry, University of Manchester Medical School, Manchester
{dagger} From the Rowett Research Institute, Aberdeen
{ddagger} From the Department of Histopathology, Wythenshawe Hospital, Manchester

Address for correspondence and reprints: Dr J C Anderson, Department of Biochemistry, University of Manchester Medical School, Oxford Road, Manchester M13 9PT.

Pyridinoline, a collagen specific covalent crosslink, was quantified in acid hydrolysates of human aorta using a non-equilibrium inhibition ELISA. The study was based on specimens from seven cases of aortic dissection and from seven control subjects whose death was unrelated to thoracic aortic dissection. There were no significant differences in the amounts or concentrations of pyridinoline in aortas with dissecting aneurysms compared with normal tissue, thus excluding the possibility of a causative relation between the degree of pyridinoline crosslinking of collagen molecules and dissection of the thoracic aorta. In all cases, however, the number of pyridinoline crosslinks per molecule of collagen in the ascending aorta and arch approached the theoretical maximum for lysyl derivatives and was as high as that present in cartilage. Thus in this region of the vessel pyridinoline represents the major stabilising crosslink of collagen. In contrast, the number of pyridinoline crosslinks per collagen molecule decreased maximally by a factor of 10 between the arch and the proximal regions of the descending thoracic aorta. This suggests a possible correlation between the rigidity of collagen fibres and the forces exerted on the aortic wall during diastole and systole.

KEYWORDS pyridinoline; collagen crosslink; thoracic aorta; dissecting aneurysm


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.