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© 1983 British Society for Rheumatology

research-article

A COMPARISON OF PLATELET COUNT AND ACUTE PHASE PROTEINS IN THE MEASUREMENT OF DISEASE ACTIVITY IN RHEUMATOID ARTHRITIS

J.S. DIXON, M.F.R. MARTIN, H.A. BIRD and V. WRIGHT

Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate and University Department of Medicine, General Infirmary Leeds

Correspondence to: Address correspondence to Dr. J.S. Dixon. Royal Bath Hospital, Cornwall Road, Harrogate, HG1 2PS.

Platelet count (PC) was compared with standard acute phase reactants (ESR, plasma viscosity and C-reactive protein) and clinical measurements to assess its usefulness as a measure of disease activity in 165 patients with active rheumatoid arthritis. Although PC was elevated (>400x1019–1) in 45% of patients and was seen to fall under the influence of second-line drugs, it was considered to be unsuitable as an indication of disease activity since levels fall for reasons other than disease improvement.

KEY WORDS: Rheumatoid arthritis, Acute phase proteins, platelet counts


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