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© 1984 British Society for Rheumatology

research-article

A PHARMACOKINETIC COMPARISON OF CHOLINE MAGNESIUM TRISALICYLATE AND SOLUBLE ASPIRIN

M. HELLIWELL1, T. GIBSON1,, D. BERRY2 and G. VOLANS2

1Department of Rheumatology, Guy's Hospital London SEI9RT
2Poisons Unit, Guy's Hospital London SE1 9RT

Correspondence to: Address correspondence to Dr. Gibson.

Claims that twice-daily dosage of choline magnesium trisalicylate (CMT) may alter salicylate disposal kinetics and result in sustained plasma levels were examined. Plasma levels, urine excretion and pharmacokinetics of salicylate were estimated in six men following the recommended twice-daily dose of CMT and a smaller dose of soluble aspirin. The plasma salicylate levels achieved with CMT were lower than those seen in previous studies but this probably reflected differences of methodology. Salicylate levels were not sustained between doses and elimination rates and half-life were similar for both preparations. No major alteration of disposal kinetics could be demonstrated for CMT with the dose used in the present study.

KEY WORDS: Choline magnesium trisalicylate, Aspirin, Disposal kinetics


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