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© 1984 British Society for Rheumatology

case-report

THROMBOCYTOPENIA IN A CASE OF SYSTEMIC LUPUS ERYTHEMATOSUS: REPEATED ADMINISTRATION OF ‘PULSE’ METHYL PREDNISOLONE

C. G. MACKWORTH-YOUNG, M. J. WALPORT and G. R. V. HUGHES

The Rheumatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital Du Cane Road, London W12 OHS

Correspondence to: Address correspondence to Dr C. G. Mackworth-Young.

The case of a young woman with systemic lupus erythematosus (SLE) is reported in whom thrombocytopenia was a major feature of her disease. She was given three courses of ‘pulse’ intravenous methyl prednisolone (IVMP) on separate occasions as treatment for profound thrombo-cytopenia. A diminishing response in platelet count was obtained following each course. She received a further course of IVMP for treatment of a nephritis, with a moderate platelet response: this may have been related in part to concomitant oral cyclophosphamide.

IVMP may be an effective treatment for SLE-associated thrombocytopenia but repeated courses may result in a reduced platelet response.

KEY WORDS: Systemic lupus erythematosus, Thrombocytopenia, Pulse steroid therapy


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