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© 1985 British Society for Rheumatology

research-article

LYMPHOCYTE PROLIFERATIVE RESPONSES TO BACTERIAL ANTIGENS IN B27-ASSOCIATED ARTHROPATHIES

P. J. SHELDON and P. A. PELL

Department of Microbiology, University of Leicesier, University Road Leicester LE1 7RH

Correspondence to: Address correspondence to Dr. P. J. Sheldon

Lymphocyte transformation tests to Yersinia enterocolitica 0:3 and 0:6, Klebsiella pneumoniae and Streptococcus faecalis antigens have been carried out in ankylosing spondylitis, reactive arthritis/Reiter's disease and controls. Ankylosing spondylitis cases gave significantly lower responses than reactive arthritis/Reiter's to Yersinia enterocolitica 0:6 (p = 0.003) and Klebsiella pneumoniae (p = 0.008), and less than controls to S. faecalis (p = 0.008).

It appears, therefore, that within the B27 arthritis population there is heterogeneity of cell-mediated response to certain enteric bacteria, with the hyporesponders manifesting ankylosing spondylitis and the hyper-responders reactive arthritis/Reiter's disease.

KEY WORDS: Lymphocyte responses, Bacteria, B27 arthropathies


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