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© 1985 British Society for Rheumatology

research-article

MULTIPLE VASCULOPATHIES AND HEPATITIS B IN A FAMILY

ARSHAG D. MOORADIAN and RIDA FRAYHA

Division of Rheumatology, Department of Internal Medicine, American University Medical Center Beirut, Lebanon

Correspondence to: Address correspondence to Dr. A. D. Mooradian, Department of Medicine, Division of Endocrinology, University of Minnesota, Box 91 Mayo Memorial Building, 515 Delaware Street S.E., Minneapolis, Minnesota 55455, USA

A unique kindred with an unusual high incidence of serological markers of past or present hepatitis B infection was studied. None of eight relatives had clinical or chemical evidence of hepatitis and all were negative for IgM anti-hepatitis A, but four sisters, each with at least one hepatitis B marker, had features of rheumatic disorders. The index patient had polyarteritis nodosa, two sisters had Raynaud's disease, and the fourth an unclassifiable non-inflammatory polyarthralgia. A daughter of one sister with Raynaud's developed the aortic arch syndrome. There was no segregation of HLA-A, -B and -c alleles with hepatitis B infection. The intrafamilial occurrence of B virus infection and multiple vasculopathies suggests a wider role of this virus in inflammatory vessel diseases.

KEY WORDS: Familial vasculitis, Hepatitis B, Takayasu's disease, Polyarteritis nodosa


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