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© 1985 British Society for Rheumatology

research-article

DECREASED CHEMILUMINESCENT ASSOCIATED PHAGOCYTIC RESPONSE OF PERIPHERAL BLOOD MONONUCLEAR CELLS TO CHLAMYDIA TRACHOMATIS IN PATIENTS WITH HLA-B27+ ANTERIOR UVEITIS

DENIS WAKEFIELD1, PAUL ROBINSON1, JOAN EASTER1, DORIS GRAHAM2 and RONALD PENNY1

1Department of Immunology, St. Vincent's Hospital; Schools of Medicine and Pathology, University of New South Wales Sydney
2Department of Microbiology, University of Melbourne Australia

Correspondence to: Address correspondence to Dr. D. Wakefield, School of Pathology, University of NSW, P.O. 1, Kensington, NSW 2033, Australia.

The chemiluminescent (CL) associated phagocytic response of peripheral blood monocytes to two serovars of Chlamydia trachomatis, Shigella flexneri and zymosan was assessed in a group of 26 patients with anterior uveitis (AU). HLA-B27+ patients with AU, when compared to HLA-B27– patients with AU and appropriate controls, had a significantly decreased CL response to C. trachomatis but no difference between groups in the response to S. flexneri and zymosan. The decreased chemiluminescent (phagocytic) response of mononuclear phagocytes to Chlamydiae may indicate an important abnormality in the pathogenesis of HLA-B27+ AU.

KEY WORDS: Chemiluminescence, HLA-B27, Uveitis, Chlamydia trachomatis


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