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© 1986 British Society for Rheumatology

research-article

CLINICAL ADVANTAGES FROM MEASUREMENT OF IgM-RHEUMATOID FACTOR BY ENZYME IMMUNOASSAY

J. HIGHTON1,, P. A. HESSIAN1, B. SMALL2 and D. G. PALMER1

1Wellcome Medical Research Institute, University of Otago Medical School P.O. Box 913, Dunedin, New Zealand
2Department of Preventive and Social Medicine, University of Otago Medical School Dunedin, New Zealand

Correspondence to: Address requests for reprints to Dr J.Highton

Two enzyme immunoassays for rheumatoid factor (RF) were compared with the traditional latex agglutination test. Preference is expressed for an ELISA specific for IgM-RF because it yields specific, quantitative results. Variability of this assay was least in sera containing moderate levels of RF and it was less precise at low concentrations. Survey of a random selection from the local population showed a similar prevalence of IgM-RF positivity as revealed by previous surveys using agglutination techniques. We conclude that measurement by ELISA yields no great increase in the discriminative ability of RF testing.

KEY WORDS: Rheumatoid factor, ELISA, Normal population, Rheumatoid arthritis


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