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© 1986 British Society for Rheumatology

research-article

A DOUBLE-BLIND STUDY OF THE SIMPLE ANALGESIC NEFOPAM IN RHEUMATOID ARTHRITIS

P. EMERY and T. GIBSON

Rheumatology Department, Guy's Hospital London SE1 9RT, UK

Correspondence to: Address correspondence to Dr. T. Gibson.

The role of pure analgesics in the management of rheumatoid arthritis (RA) remains uncertain. In a double-blind cross-over study of 27 patients, nefopam was a more effective analgesic than placebo when given as a supplement to anti-inflammatory drugs. Both early morning stiffness and grip strength were also improved, suggesting that these are associated with pain perception rather than any other aspect of inflammation. Side-effects occurred in 9 (35%) on nefopam and none on placebo. The results suggest a valuable supplementary role for analgesics such as nefopam in the treatment of RA.

KEY WORDS: Pain relief, Rheumatoid arthritis, Nefopam


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