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© 1986 British Society for Rheumatology

research-article

ANTI-INFLAMMATORY EFFECTS OF ULTRASOUND THERAPY: EVIDENCE FOR A MAJOR PLACEBO EFFECT

I. HASHISH, W. HARVEY and M. HARRIS

Department of Oral and Maxillo-Facial Surgery, Institute of Dental Surgery Grays Inn Road, London WC1X8LD, UK

Correspondence to: Address correspondence to Mr. I. Hashish

The value of therapeutic ultrasound (US) for reducing inflammation was tested in a double-blind controlled study in 150 patients following surgical removal of impacted lower third molars. Facial swelling, trismus, pain and serum C-reactive protein (CRP) were significantly reduced in the US-treated groups and in a placebo group (‘mock’ US) compared with an untreated control group. The majority of the anti-inflammatory activity was attributable to the placebo effect, and the highest intensity of US (1.5 W.cm–2) was consistently less beneficial than the lower intensities (0.1 and 0.5 W.cm–2) and the mock US.

KEY WORDS: Ultrasound, Inflammation, Placebo


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