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© 1986 British Society for Rheumatology

research-article

PRELIMINARY EVIDENCE FOR GUT INVOLVEMENT IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS?

A. W. SEGAL1,, D. A. ISENBERG2, V. HAJIROUSOU2, SUSAN TOLFREE3, JILL CLARK3 and M. L. SNAITH2

1Department of Haematology, the Faculty of Clinical Sciences, University College London WC1, UK
2Department of Rheumatology and Rehabilitation, the Faculty of Clinical Sciences, University College London WC1, UK
3Department of Medical Physics, the Faculty of Clinical Sciences, University College London WC1, UK

Correspondence to: Address correspondence to Dr. A. W. Segal

111Indium leucocyte scans were performed on 26 patients with active rheumatoid arthritis. An abnormal localization of radioactivity was observed in the gut of 12 of these patients, generally in the region of the terminal ileum, caecum and ascending colon. No difference was found in the intake of nonsteroidal anti-inflammatory drugs between those with positive and negative scans. Two patients with positive scans were on no medication. These observations suggest the possibility of a primary role for a gastrointestinal lesion in the aetiology of rheumatoid arthritis, although these abnormalities could be secondary or unrelated.

KEY WORDS: Gut, Rheumatoid arthritis, Indium leucocyte scan


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