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© 1986 British Society for Rheumatology

research-article

LACK OF CORRELATION BETWEEN CLINICAL DISEASE ACTIVITY AND ERYTHROCYTE SEDIMENTATION RATE, ACUTE PHASE PROTEINS OR PROTEASE INHIBITORS IN ANKYLOSING SPONDYLITIS

N. J. SHEEHAN1,, B. M. SLAVIN2, M. P. DONOVAN2, J. N. MOUNT2 and J. A. MATHEWS1

1Department of Rheumatology St. Thomas' Hospital London SE1 7EH, UK
2Department of Chemical Pathology and Metabolic Disorders, St. Thomas' Hospital London SE1 7EH, UK

Correspondence to: Address correspondence to Dr. N. J. Sheehan

Disease activity was assessed clinically and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), orosomucoid, {alpha}1-antitrypsin ({alpha}1 AT) and {alpha}2-macroglobulin ({alpha}2M) were measured in 65 patients with ankylosing spondylitis (AS). Positive correlations were found between ESR and the acute phase proteins (APP), CRP, orosomucoid and {alpha}1AT, but none of these variables correlated with the clinical assessment of activity. No relationship was demonstrated between the protease inhibitor, {alpha}2M and clinical activity, ESR or any of the APP.

While the treatment of AS remains predominantly symptomatic, routine management of patients should continue to be founded on the clinical assessment of disease activity rather than on laboratory indices of inflammation.

KEY WORDS: Ankylosing spondylitis, Clinical assessment, Erythrocyte sedimentation rate, Acute phase proteins, Protease inhibitors


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