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© 1987 British Society for Rheumatology

research-article

INCREASED INTESTINAL PERMEABILITY IN PATIENTS WITH RHEUMATOID ARTHRITIS: A SIDE-EFFECT OF ORAL NONSTEROIDAL ANTI-INFLAMMATORY DRUG THERAPY?

R. T. JENKINS, P. J. ROONEY, D. B. JONES, J. BIENENSTOCK and R. L. GOODACRE

Intestinal Disease Research Unit, Departments of Pathology and Medicine, McMaster University Hamilton, Ontario, Canada

Correspondence to: Address correspondence to Dr. R. T. Jenkins, Department of Pathology, Room 2V17c, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5

Intestinal permeability in controls and in patients with active rheumatoid arthritis was assessed by measuring the radioactivity in 24-h urine collections after oral administration of 51Cr-EDTA. Intestinal permeability in the patients was found to be significantly increased in comparison to controls. Of the patients, 6/7 (86%) not taking any prescribed nonsteroidal anti-inflammatory drug (NSAID) at the time of study had normal results, whereas 23/29 patients (79%) taking prescribed NSAIDs displayed increased intestinal permeability. It has not been determined beyond doubt whether this finding is due to disease process or therapy with oral NSAIDs.

KEY WORDS: Intestinal permeability, Rheumatoid arthritis, 51Cr-EDTA, Nonsteroidal anti-inflammatory drugs, Prostaglandins


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