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© 1987 British Society for Rheumatology

research-article

DECREASED BIOACTIVITY OF CIRCULATING PROLACTIN IN PATIENTS WITH RHEUMATOID ARTHRITIS

I. BERCZI1,, H. COSBY2, T. HUNTER*,3, F. BARAGAR3, A. S. McNEILLY{dagger},2 and H. G. FRIESEN2

1Departments of Immunology Department of Medicine, Faculty of Medicine, University of Manitoba Winnipeg, Manitoba, Canada, R3E0W3
2Departments of Physiology Department of Medicine, Faculty of Medicine, University of Manitoba Winnipeg, Manitoba, Canada, R3E0W3
3Departments of Rheumatic Disease Unit. Department of Medicine, Faculty of Medicine, University of Manitoba Winnipeg, Manitoba, Canada, R3E0W3

Correspondence to: Address correspondence to Dr. I. Berczi.

Growth hormone and prolactin (PRL) were measured by radio-immunoassay in sera of 36 patients with rheumatoid arthritis (24 females and 12 males) and of 50 normal blood donors (25 males and 25 females). The bioactivity of PRL was also determined for both groups, using the Nb2 rat lymphoma proliferation assay. Although no significant difference was found between serum PRL values of patients and controls when determined by radio-immunoassay, the bioactivity of PRL was significantly decreased in patients sera, when compared to values obtained in age and sex-matched controls. This decreased PRL bioactivity could not be attributed to drug treatments administered to the patients examined.

KEY WORDS: Rheumatoid arthritis, Prolactin bioactivity, Prolactin immunoreactivity

* Present address: Shaughnessy Hospital, 4500 Oak St., Vancouver, B.C., Canada.

{dagger}Present address: MRC Reproductive Biology Unit, 37 Chalmers St., Edinburgh EH3 9EW, UK.


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