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© 1988 British Society for Rheumatology

research-article

ANTI La(SSB) IDENTIFIES A DISTINCTIVE SUBGROUP OF SYSTEMIC LUPUS ERYTHEMATOSUS

P. J. MADDISON1,, D. A. ISENBERG2, N. J. GOULDING1, J. LEDDY1 and R. P. SKINNER1

1Royal National Hospital for Rheumatic Diseases Upper Borough Walls, Bath BAI IRL
2Bloomsbury Rheumatology Department, UCHIMiddlesex Hospital London WC1, UK

Correspondence to: Address correspondence to Dr. Maddison.

The relevance of antibodies for La(SSB) as a marker of a distinctive systemic lupus erythematosus (SLE) subset was studied in 185 lupus patients. Anti La was detected in 39 (21%) and was accompanied invariably by anti Ro. Clinically, anti La-positive patients were distinguished by a later age of disease onset, and a low frequency of lupus nephritis. In common with other anti Ro-positive patients they showed a high frequency of keratoconjunctivitis sicca. Anti La identified patients with higher titres of anti Ro antibodies and was significantly associated with HLA-DR3. Serological markers such as these are useful for identifying more homogeneous populations of SLE patients for studies of aetiology and pathogenesis.

KEY WORDS: SLE, anti La(SSB), anti Ro(SSA), Elderly lupus


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