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© 1988 British Society for Rheumatology

case-report

COEXISTENCE OF RHEUMATOID ARTHRITIS, ANKYLOSING SPONDYLITIS AND DERMATOMYOSITIS IN A PATIENT WITH DIABETES MELLITUS AND THE ASSOCIATED LINKED HLA ANTIGENS

M. A. SATTAR1,, A. A. AL-SUGHYER1 and R. SIBOO2

1Department of Medicine,Faculty of Medicine, Kuwait University Kuwait (Arabian Gulf)
2Division of Clinical Immunology, Department of Microbiology, Faculty of Medicine, Kuwait University Kuwait (Arabian Gulf)

Correspondence to: Address correspondence to Dr. M. A. Sattar, Department of Medicine, Kuwait University, P.O. Box 24923, Safat, Zip Code 13110, Safat, Kuwait, Arabian Gulf.

A patient is described who had insulin-dependent diabetes mellitus for 2 years, prior to developing rheumatoid arthritis and then subsequently ankylosing spondylitis and dermatomyositis. Diagnostic criteria for all diseases are fulfilled. HLA typing revealed the presence of HLA A2, A9, B8, B27, DR3 and DR4 antigens. The concomitant coexistence of diabetes mellitus, rheumatoid arthritis, ankylosing spondylitis and dermatomyositis appears to have occurred in an individual genetically susceptible to these diseases.

KEY WORDS: Connective-tissue disease, Hyperglycaemia, Tissue type, Susceptibility genes.


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