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© 1988 British Society for Rheumatology

other

THE EFFECT OF INDOMETHACIN ON THE PSYCHOMOTOR FUNCTION OF PATIENTS WITH RHEUMATIC DISEASES

T. PULLAR, O. MYALL, J. R. M. HAIGH, J. R. LOWE, J. S. DIXON and H. A. BIRD

Departments of Medicine and Pharmacology, University of Leeds

Correspondence to: Address correspondence to Dr. T. Pullar, University Department of Medicine, The General Infirmary, Leeds LSI 3EX. UK.

We have compared the effect of single and multiple doses of indomethacin and placebo on objective measurements of psychomotor impairment in patients. Following a single 50 mg dose (n = 8), indomethacin produced psychomotor disturbance in only those patients who had no recent history of NSAID exposure. After multiple doses of indomethacin (25 and 50 mg tid for 5 days), no significant psychomotor impairment was observed. We conclude that other NSAIDs may induce cross-tolerance to the psychomotor effects of indomethacin. Tachyphylaxis may develop to the psychomotor disturbance caused by indomethacin.

KEY WORDS: Tachyphylaxis, Tolerance, NSAID, Central nervous system, Flicker fusion threshold, Choice reaction times


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