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© 1989 British Society for Rheumatology

research-article

FACTORS INFLUENCING PERTECHNETATE UPTAKE BY RABBIT KNEES

D. R. BARD and D. P. PAGE-THOMAS

Strangeways Research Laboratory Worts; Causeway, Cambridge CBJ 4RN

Correspondence to: Correspondence to Dr. Bard

The accumulation of radioactivity over rabbit knees immediately after the injection of 99mTc-pertechnetate or one of two 99mTc-labelled particulate preparations has been measured in animals with and without experimental arthritis. The results indicate that in inflamed, but not normal joints, a peak of radioactivity is detectable within 9 seconds of injection and suggest that the rate of accumulation of radioactivity over the joint may be a more sensitive indicator of inflammatory activity than measurement at a fixed time. Clearance from the circulation and tissue distribution of the three radioactive preparations were also measured.

KEY WORDS: Experimental arthritis, Pertechnetate, Colloids, Rabbits, Radioactive scanning, Inflammation, Knee joints


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