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© 1989 British Society for Rheumatology

case-report

RHEUMATOID ARTHRITIS AND MOTOR NEURONE DISEASE—AN ASSOCIATION?

W. SCHADY, R. A. METCALFE and P. J. L. HOLT*

*University Department of Rheumatology, Manchester Royal Infirmary Oxford Road, Manchester M13 9WL, UK
University Department of Neurology, Manchester Royal Infirmary Oxford Road, Manchester M13 9WL, UK

Correspondence to: Address Correspondence to: Dr. A. Schady

Three patients with rheumatoid arthritis and motor neurone disease are presented. The neurological syndrome supervened after 2, 19 and 23 years of polyarthritis and led to death within 4 years. The diagnosis of motor neurone disease was confirmed at post mortem in one case. Common immunological mechanisms may account for this previously unreported association.

KEY WORDS: Polyarthritis, Amyotrophic lateral sclerosis, Motor neuropathy, Foot drop


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