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© 1989 British Society for Rheumatology

research-article

BONE GLA PROTEIN (BGP) LEVELS AND BONE TURNOVER IN RHEUMATOID ARTHRITIS

M. MAGARO, L. ALTOMONTE, LUISA MIRONE, A. ZOLI and G. CORVINO

Istituto di Clinica Medica, Divisione di Reumatologia, Universita' Cattolica Sacro Cuore Largo A. Gemelli 8, 00168, Roma, Italy

Correspondence to: Correspondence to Prof. Magaro

Bone GLA protein (BGP) and other biochemical indices of bone turnover were measured in 42 female patients with rheumatoid arthritis (RA) and in a group of normal subjects matched for sex and age.

Mean serum BGP concentrations were significantly higher in patients with active arthritis than in patients with mild activity (p<0.01) and controls (p<0.01). No significant difference was found in serum BGP levels and in other parameters of bone turnover when the patients were stratified according to functional class or duration of disease. There was a correlation between BGP and alkaline phosphatase levels only in RA patients with high activity of disease

Our data suggest an accelerated bone turnover in patients with active RA. We infer that in such patients the impairment of bone metabolism is a determinant of RA-associated osteopenia. Disease activity rather than functional impairment or duration of arthritis should be regarded as a factor in the bone loss of RA.

KEY WORDS: Bone GLA protein (BGP), Bone turnover, Rheumatoid arthritis


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