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© 1989 British Society for Rheumatology

research-article

A COMPARISON OF GLUTATHIONE REDUCTASE AND GLUTATHIONE PEROXIDASE ACTIVITES IN PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY ADULTS

J. BRAVEN*,, N. ANSARI*, D. P. FIGGITT*, A. FISHER*, CHRISTINE LUDERS*, P. HICKLING{dagger} and MARY WHITTAKER*

*Department of Environmental Sciences, Plymouth Polytechnic Plymouth, Devon, UK
{dagger}Department of Rheumatology, Plymouth General Hospital Plymouth, Devon

Correspondence to: Correspondence to Dr. Braven.

A 30% increase in erythrocyte glutathione peroxidase (GP) activity was found in patients with rheumatoid arthritis when compared with healthy controls (p = 0.001) whereas the increase in glutathione reductase (GR) was statistically insignificant. No correlation was found between the activities of the enzymes and the erythrocyte sedimentation rate (ESR). The enzyme activities were independent of age, sex, or type of drug treatment of the patients. A possible interpretation of the results is presented.

KEY WORDS: Glutathione peroxidase, Glutathione reductase, Rheumatoid arthritis, Disease activity, Thiol, Peroxides


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