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© 1989 British Society for Rheumatology

research-article

PROSTACYCLIN PRODUCTION BY HUMAN UMBILICAL VEIN ENDOTHELIUM IN RESPONSE TO SERUM FROM PATIENTS WITH SYSTEMIC SCLEROSIS

C. M. HOLT, J. MOULT, N. LINDSEY, P. HUGHES, M. GREAVES* and N. R. ROWELL{dagger}

University Department of Medicine, Northern General Hospital Sheffield
*University Department of Haematology, Royal Hallamshire Hospital Sheffield
{dagger}University Department of Dermatology, General Infirmary at Leeds Leeds

Correspondence to: Address for correspondence: Dr. P. Hughes, Department of Medicine, Clinical Sciences Centre, Northern General Hospital, Sheffield S5 7AU.

Sera from 29 patients with systemic sclerosis and 30 normal controls were examined for their effect on prostacyclin release by human umbilical vein endothelial cells during periods of response of 15 min and 72 h and for their effect on endothelial growth and 3H-thymidine uptake during a 72-h culture period. In contrast to previous reports, no significant differences were detected between patient and control sera in their effect on endothelial cell prostacyclin release, growth or 3H-thymidine uptake.

KEY WORDS: Scleroderma, Endothelial cells, Blood vessels, Prostanoid metabolism


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