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© 1989 British Society for Rheumatology

research-article

A STUDY OF TOLERANCE TO THE PSYCHOMOTOR EFFECTS OF INDOMETHACIN IN HEALTHY VOLUNTEERS

T. PULLAR, S. DALE, J. LOWE and H. BIRD

Departments of Medicine and Pharmacology, University of Leeds

Correspondence to: Address correspondence to Dr. Pullar, University Department of Medicine, Martin Wing, The General Infirmary, Leeds LS1 3EX

We have examined the effect of single dose indomethacin 50 mg on objective measurements of psychomotor function and whether this effect is altered by pretreatment with indomethacin 25 rng t.i.d. for 7 days in 10 healthy volunteers (5 male, 5 female; age 20–54 y). One hour after a single dose of indomethacin 50 mg there was significant impairment of psychomotor function (critical flicker fusion frequency threshold and choice reaction time) (Wilcoxon p<0.05). Pretreatment with indomethacin 25 mg t.i.d. for 7 days prevented this impairment. Thus we conclude that tolerance occurs over the course of a week to the psychomotor effects of indomethacin.

KEY WORDS: Tachyphylaxis, Tolerance, NSAID, Critical flicker fusion threshold, Choice reaction time


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