Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by PULLAR, T.
Right arrow Articles by BIRD, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by PULLAR, T.
Right arrow Articles by BIRD, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 British Society for Rheumatology

research-article

A STUDY OF TOLERANCE TO THE PSYCHOMOTOR EFFECTS OF INDOMETHACIN IN HEALTHY VOLUNTEERS

T. PULLAR, S. DALE, J. LOWE and H. BIRD

Departments of Medicine and Pharmacology, University of Leeds

Correspondence to: Address correspondence to Dr. Pullar, University Department of Medicine, Martin Wing, The General Infirmary, Leeds LS1 3EX

We have examined the effect of single dose indomethacin 50 mg on objective measurements of psychomotor function and whether this effect is altered by pretreatment with indomethacin 25 rng t.i.d. for 7 days in 10 healthy volunteers (5 male, 5 female; age 20–54 y). One hour after a single dose of indomethacin 50 mg there was significant impairment of psychomotor function (critical flicker fusion frequency threshold and choice reaction time) (Wilcoxon p<0.05). Pretreatment with indomethacin 25 mg t.i.d. for 7 days prevented this impairment. Thus we conclude that tolerance occurs over the course of a week to the psychomotor effects of indomethacin.

KEY WORDS: Tachyphylaxis, Tolerance, NSAID, Critical flicker fusion threshold, Choice reaction time


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.