Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by TAHA, A. S.
Right arrow Articles by RUSSELL, R. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by TAHA, A. S.
Right arrow Articles by RUSSELL, R. I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 British Society for Rheumatology

research-article

EVALUATION OF THE EFFICACY AND COMPARATIVE EFFECTS ON GASTRIC AND DUODENAL MUCOSA OF ETODOLAC AND NAPROXEN IN PATIENTS WITH RHEUMATOID ARTHRITIS USING ENDOSCOPY

A. S. TAHA, S. McLAUGHLIN, R. D. STURROCK and R. I. RUSSELL

Centre for Rheumatic Diseases, and Gastroenterology Unit, Royal Infirmary Glasgow G31 2ER

Correspondence to: Correspondence to Dr Taha, Gastroenterology Unit, Royal Infirmary, Glasgow G31 2ER

The therapeutic efficacy and upper gastrointestinal side effects of a twice daily dose of 300 mg etodolac and 500 mg naproxen were compared in 30 hospital out-patients with active rheumatoid arthritis. Drugs were taken for 4 weeks in a double-blind, randomized, parallel group, single centre study. Rheumatological, endoscopic and laboratory assessments were performed at the start and on completion of the study.

Mucosal lesions developed in only three (20%) patients of the etodolac group and they all had low endoscopy scores, compared to eight (53%) patients of the naproxen group with significantly worse endoscopy scores (p <0.05). Lesions were asymptomatic in all but one patient (on naproxen), and the gastric antrum was the commonest region involved. Of the 11 patients who developed endoscopic abnormalities in both groups, seven (64%) were moderate to heavy smokers. Etodolac had a similar antiarthritic effect to naproxen. but it appears to be better tolerated by the upper gastrointestinal mucosa as shown by endoscopy.

KEY WORDS: Anti-inflammatory, NSAID, PGE2, Gastric antrum, Gastric ulcer, Gastric erosion, Tolerance


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.