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© 1989 British Society for Rheumatology

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SIALOCHEMISTRY IN JUVENILE CHRONIC ARTHRITIS

A. SIAMOPOULOU*,1, A. K. MAVRIDIS{dagger}, S. VASAKOS{ddagger}, P. BENECOS*, A. G. TZIOUFAS{dagger} and A. P. ANDONOPOULOS{dagger}

*Department of Paediatrics,Medical School, University of loannina 451 10 loannina, Greece
{dagger}Department of Medicine,Medical School, University of loannina 451 10 loannina, Greece
{ddagger}Department of Biological Chemistry, Medical School, University of loannina 451 10 loannina, Greece

Correspondence to: 1Correspondence to Dr. Siamopoulou.

Stimulated parotid gland secretions collected from 16 patients with juvenile chronic arthritis (JCA) were analysed and the results compared with those obtained from 83 healthy sex-, age- and socioeconqmic status-matched children. Parotid salivary flow rate was measured and the saliva samples were assayed for calcium, phosphorus, potassium, chloride, sodium, urea, lysozyme, amylase and immunoglobulin levels (IgA, IgG, IgM). Our results showed that parotid flow rate (PFR) values in JCA patients were not statistically different from those in healthy controls. However, the mean salivary concentrations of calcium, phosphorus, potassium, lysozyme and IgA were significantly lower in the patients. These data could provide an explanation for the increased incidence of caries and gingivitis observed in JCA.

KEY WORDS: Parotid flow, Calcium, Phosphorus, Lysozyme, IgA, Dental caries


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