© 1989 British Society for Rheumatology
other |
SERUM AND SYNOVIAL FLUID OSTEOCALCIN (BONE GLA PROTEIN) LEVELS IN JOINT DISEASE
*Inserm Unit 234, Hôpital Edouard Herriot Lyon, France
Rheumatology Unit, Bristol Royal Infirmary Bristol, UK
Correspondence to:
1Correspondence to Dr. Campion, Section of Rheumatology, Rush Presbyterian St. Lukes Medical Center, 1653 West Congress Parkway, Chicago, IL 60612-3864, USA.
Osteocalcin (bone gla protein) is a sensitive marker of bone turnover in metabolic disease. Using a well characterized antiserum (R 102M) we have assayed serum and synovial fluid samples from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) and related levels to serological and radiological markers of disease. There were 21 patients with RA (mean age 58.2 years, 15 F) and 33 with OA (mean age 69.2, 28 F). Paired serum and synovial fluids (SF) were available in 19 RA patients and 30 OA patients. Serum osteocalcin levels were related to age-sex-matched normals and to a small group of elderly disease controls. Serum levels tended to be lower in RA than controls, but not significantly so: RA 5.56 (3.67); control 6.09(2.54) ng/ml; expressed as mean (SD) and the mean serum/SF ratio was 0.88 (0.86). The results were much more variable in OA (mean serum osteocalcin 6.1 (3.9)). Elevated levels were mainly due to a small number of patients with a destructive form of OA and were higher than those with non-destructive OA (10.3 (3.5), n=20, versus 3.83 (1.6), n=W). Patients with non-destructive OA had a lower serum osteocalcin than age-/sex-matched normals. In this study, synovial fluid levels were usually less than serum concentrations, but in two RA and four OA patients the ratio was reversed, suggesting local production. Osteocalcin may be an important marker of bone activity in OA.
KEY WORDS: Osteocalcin (bone gla protein), Serum, Synovial fluid, Rheumatoid arthritis, Osteoarthritis, Destructive osteoarthritis
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. J. Hunter, D. Hart, H. Snieder, P. Bettica, R. Swaminathan, and T. D. Spector Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins Rheumatology, November 1, 2003; 42(11): 1311 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Garnero, M Piperno, E Gineyts, S Christgau, P D Delmas, and E Vignon Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage Ann Rheum Dis, June 1, 2001; 60(6): 619 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Salisbury and M Sharif Relations between synovial fluid and serum concentrations of osteocalcin and other markers of joint tissue turnover in the knee joint compared with peripheral blood Ann Rheum Dis, September 1, 1997; 56(9): 558 - 561. [Abstract] [Full Text]
|
|