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© 1989 British Society for Rheumatology

other

THE EFFECT OF CPH 82 ON THE GROWTH OF HUMAN LYMPHOCYTES IN VITRO. DEFINITION OF CYTOBIOLOGICAL ACTION

S. RANTAPÄÄ DAHLQVIST*,, B. NORBERG{dagger}, K. SONDELL{dagger}, I. NORDENSON{ddagger} and G. HOLMGREN{ddagger}

*Department of Rheumatology,University Hospital S-901 85 Umei, Sweden
{dagger}Blood Centre, University Hospital S-901 85 Umei, Sweden
{ddagger}Department of Clinical Genetics, University Hospital S-901 85 Umei, Sweden

Correspondence to: Correspondence to Dr S. RantapÄÄ Dahlqvist.

A drug composed of two semisynthetic podophyltine derivatives, CPH 82, has recently been launched for the treatment of severe rheumatoid arthritis. The present in vitro study of PHA-stimulated human T-lymphocytes showed that CPH 82 arrested cell division in a metaphase-like configuration. The cell cycle effects of CPH 82 were indistinguishable from the cell cycle effects of the classical microtubule depolymerizers, Colcemid (a colchicine derivative) and podophyllotoxin. A CPH 82 concentration of 1 (µg/ml, which is close to therapeutic serum concentrations, had an almost maximal effect on cell division. It is suggested that at least part of the anti-inflammatory effect of CPH 82 is due to a colchicine-like activity on, for example, proliferating lymphocytes.

KEY WORDS: Podophylline derivative, CPH 82, Antimitotic effects, Arrest


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