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© 1989 British Society for Rheumatology

other

CORRELATION BETWEEN CLINICAL AND LABORATORY FINDINGS WHEN E WHOLE BLOOD FILTERABILITY RATE IS MODIFIED BY TICLOPIDINE IN THE TREATMENT OF RHEUMATOID ARTHRITIS

G. CIUFFETTI1, A. CIACCA, MICHELE MERCURI, RITA LOMBARDINI, G. MARAGONI and ANNA MARIA SCARPONI

2nd Department of Internal Medicine, Perugia University Perugia, Italy

Correspondence to: 1Correspondence to Dr. Ciuffetti, 2nd Department of Internal Medicine, Policlinico Monteluce, Via Bruna-monti, 06100 Perugia, Italy

This double-blind study assessed the effects of oral ticlopidine versus placebo on whole blood filterability in two homogenous groups of 20 rheumatoid arthritis patients taking one NSAID. The patients' clinical progress was monitored to see if modifications in the whole blood filterability rate could be correlated with any improvement in the clinical picture. Our results showed treatment with ticlopidine significantly (p<0.01) improved both the ESR (–28%) and the whole blood filterability rate (–15%), pain (–24%), and morning stiffness (–28%). These clinical benefits correlated with improvement in the whole blood filterability rate. Clinical benefits may have resulted from improved perfusion and transport of NSAID to target tissues.

KEY WORDS: Non-steroidal anti-inflammatory drugs, Efficacy, Haemorheology, Platelet aggregation, Red cell deformability, Plasma fibrinogen


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